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	Supplier	Miltenyi Biotec
	Catalog #:	130-099-699 (View supplier product page)
	Size	100 Tests in 1 ml
	Price	$360.00
	Antigen	Catenin p120 (pT916)
	Clone	REA129
	Host	Human
	Isotype	IgG1
	Conjugate	PerCP-Vio700
	Target Species	Human, Mouse
	Applications	FC
	Description	Clone REA129 recognizes the T916-phosphorylated form of p120 Catenin, a prototypic member of subfamily of armadillo-domain (ARM) proteins. p120 ARM domain displays 22% homology to other ARM-domain proteins such as β-catenin and plakoglobin, which are basically cadherin binding proteins, suggesting the involvement of p120 in binding to cadherin. p120 associates with most classical (type I) and nonclassical (type II) cadherins via ARM repeats 1–7 and is localised at the cell junctions, where it constitutes the cadherin complex. Functions of p120 include regulation of stability of cadherins and modulation of activity of rho GTPases in the cytoplasm. Furthermore, lack of p120 Catenin in mouse leads to tumor development, suggesting its further role as tumor supressor. Phosphorylation of p120 Catenin at multiple sites regulates its various functions and it can be phosphorylated by Src and various receptor tyrosine kinases. \| Additional information: Clone REA129 displays negligible binding to Fc receptors. \|

$360.00
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Catenin p120 (pT916) Monoclonal / PerCP-Vio700 / REA129