FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-099-168 (View supplier product page)
	Size	100 Tests in 1 ml
	Price	$322.00
	Antigen	CD79b
	Clone	REA120
	Host	Cell Line
	Isotype	IgG1
	Conjugate	PE-Vio770
	Target Species	Human
	Applications	FC
	Description	Clone REA120 detects the extracellular epitope of CD79b, the beta chain of heterodimeric molecule CD79. CD79 is composed of an alpha chain (CD79a) and a beta chain (CD79b) and is associated with surface immunoglobulins (Igs) to form the B cell receptor (BCR). CD79b is 37–39 kDa type I integral membrane protein and like CD79a contains an intracellular immunoreceptor tyrosine-based activation motif (ITAM). CD79a/CD79b heterodimer facilitates differentiation of pre–B cells from pro–B cells, surface expression of sIg, signal transduction following antigen recognition, and enodocytosis of recognised antigens. Patients with chronic lymphocytic leukemia (CLL) B cells lack a functional BCR which is often associated with mutations in CD79b coding region. \| Additional information: Clone REA120 displays negligible binding to Fc receptors. \|

	CD79b	The B lymphocyte antigen receptor is a multimeric complex that includes the antigen-specific component, surface immunoglobulin (Ig). Surface Ig non-covalently associates with two other proteins, Ig-alpha and Ig-beta, which are necessary for expression and function of the B-cell antigen receptor. This gene encodes the Ig-beta protein of the B-cell antigen component. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]
	PE-Vio770	PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.

$322.00
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CD79b Monoclonal / PE-Vio770 / REA120