MSR1 Monoclonal / PE-Vio770 / REA148

Citations: (1)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-105-574 (View supplier product page)
Size 9 μg in 30 μl
Price $60.00
Antigen MSR1
Clone REA148
Host Human
Isotype IgG1
Conjugate PE-Vio770
Target Species Mouse
Applications FC
Description Clone REA148 recognizes mouse CD204, also known as MSR 1 or SRA (murine scavenger receptor class A type I and II). It supports the recognition and ingestion of apoptotic cells and in particular it plays a supporting role in apoptotic cell clearance in embryogenesis. CD204 is mainly expressed on tissue macrophages. | Additional information: Clone REA148 displays negligible binding to Fc receptors. |
About MSR1 and PE-Vio770
MSR1 This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
PE-Vio770 PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.
Citations
PMID 15580571
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PE-Vio770 Excitation and Emission Spectra