FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-103-818 (View supplier product page)
	Size	30 μg in 1 ml
	Price	$158.00
	Antigen	CCR6
	Clone	REA277
	Host	cell line
	Isotype	IgG1
	Conjugate	PE-Vio770
	Target Species	Mouse
	Applications	FC
	Description	Clone REA277 recognizes the CD196 antigen, a G protein–linked chemokine receptor also known as C-C chemokine receptor type 6 (CCR6). CD196 is preferentially expressed by B cells, immature dendritic cells, and subsets of T cells. The ligand of CD196 is macrophage inflammatory protein 3 alpha (MIP-3alpha) and binding subsequently transduces a signal by increasing the intracellular calcium ions level. CD196 has been shown to be important for B-lineage maturation and antigen-driven B cell differentiation, and it may regulate the migration and recruitment of dendritic and T cells during inflammatory and immunological responses. Targeting CD196 or its ligand may be a promising therapeutic strategy to alleviate atherosclerosis. \| Additional information: Clone REA277 displays negligible binding to Fc receptors. \|

	CCR6	This gene encodes a member of the beta chemokine receptor family, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. The gene is preferentially expressed by immature dendritic cells and memory T cells. The ligand of this receptor is macrophage inflammatory protein 3 alpha (MIP-3 alpha). This receptor has been shown to be important for B-lineage maturation and antigen-driven B-cell differentiation, and it may regulate the migration and recruitment of dentritic and T cells during inflammatory and immunological responses. Alternatively spliced transcript variants that encode the same protein have been described for this gene. [provided by RefSeq, Jul 2008]
	PE-Vio770	PE-Vio® 770 from Miltenyi Biotec is a red-emitting tandem fluorophore that combines pycoerythrin (PE) and Vio®770. The donor molecule, PE can be excited by the 488-nm blue, 532-nm green, or 561-nm yellow-green laser and and transfers energy to the acceptor molecule, Vio®770, which emitts light that can be captured with a 780/60 nm bandpass filter. PE-Vio®770 has an excitation peak at 565 nm and an emission peak at 775 nm and is a common alternative to PE-Cy7 and PE-H7.

$158.00
Supplier Page

CCR6 Monoclonal / PE-Vio770 / REA277