FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-106-259 (View supplier product page)
	Size	9 μg in 30 μl
	Price	$95.00
	Antigen	Ly-6A/Ly-6E
	Clone	REA422
	Host	Human
	Isotype	IgG1
	Conjugate	Vio Bright FITC
	Target Species	Mouse
	Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
	Description	Clone REA422 recognizes the mouse stem cell antigen-1 (SCA-1) antigen, a 18 kDa glycosylphosphatidylinositol (GPI) linked protein which is also known as lymphocyte antigen 6A and 6E (Ly-6A/E). Clone REA422 specifically recognizes both Ly-6E.1 and Ly-6A.2, which are gene products of the two Ly-6A/E alleles expressed in different mouse strains (Ly-6E.1: e.g. BALB/c, C3H, NZB; Ly-6A.2: e.g. C57BL/6, SJL, 129, AKR). Sca-1 is expressed on hematopoietic stem cells and progenitor cells in mouse bone marrow and is one of the defining markers for so-called KSL (c-kit+ Sca-1+ Lin-) cells. Sca-1 in combination with CD105 (Endoglin) expression has been used to define long-term repopulating hematopoietic stem cells (LTR-HSCs) in mouse bone marrow. In addition, Sca-1+ bone marrow cells also contain the mesenchymal stem cell fraction. Sca-1+ cells have been shown to give rise to hepatocytes in vivo and neural cells in vitro. Furthermore, Sca-1 is expressed on stem cells in a variety of nonhematopoietic tissues, such as adult liver, heart, and prostate. \| Additional information: Clone REA422 displays negligible binding to Fc receptors.

	Ly-6A/Ly-6E	This gene belongs to the human Ly6 gene family and encodes a glycosylphosphatidyl-inositol (GPI)-anchored cell surface protein. The protein plays an important role in T cell physiology, oncogenesis and immunological regulation. The protein is also involved in modulation of viral infection by coronaviruses, SARS-CoV, MERS-CoV and SARS-CoV-2. [provided by RefSeq, Aug 2021]
	Vio Bright FITC	Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.

$95.00
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Ly-6A/Ly-6E Monoclonal / Vio Bright FITC / REA422