FluoroFinder

	Supplier	US Biological
	Catalog #:	133213-FITC-100UL (View supplier product page)
	Size	100 μl
	Price	$681.00
	Antigen	Senataxin
	Clone	2A9
	Host	Mouse
	Isotype	IgG1 κ
	Conjugate	FITC
	Target Species	Human
	Applications	ELISA, IF, WB
	Description	Senataxin (Probable Helicase Senataxin, SETX, Amyotrophic Lateral Sclerosis 4 Protein, ALS4, AOA2, bA479K20.2, KIAA0625, SCAR1, SEN1 Homolog) (FITC) Mab 2A9

	Senataxin	This gene encodes a protein named for its homology to the Sen1p protein of fungi which has RNA helicase activity encoded by a domain at the C-terminal end of the protein. The protein encoded by this gene contains a DNA/RNA helicase domain at its C-terminal end which suggests that it may be involved in both DNA and RNA processing. Mutations in this gene have been associated with ataxia-ocular apraxia-2 (AOA2) and an autosomal dominant form of juvenile amyotrophic lateral sclerosis (ALS4). [provided by RefSeq, Jul 2008]
	FITC	Fluorescein isothiocyanate (FITC) has an excitation peak at 495 nm and an emission peak at 519 nm. The name FITC is a misnomer in that the isothiocyanate is a reactive form of this dye. Once FITC is conjugated to an antibody, it is simply Fluorescein conjugated. FITC is one of the most widely used dyes for fluorescent applications, therefore most instruments come standard with a 488 nm laser and FITC filter set up. FITC is commonly conjugated to secondary antibodies and used in applications such as flow cytometry, immunocytochemistry, and immunohistochemistry. FITC is relatively dim, sensitive to photobleaching and it is susceptible to changes is pH. There are better performing alternatives to FITC, like Vio®Bright 515, Alexa Fluor™ 488, iFluor® 488, CF®488A and DY-488. FITC is a long-time generic dye with no sole manufacturer or trademark.

	Additional Sources

Senataxin / FITC / 2A9