CD162 / MaxLight 490 /
CD162 / MaxLight 490 /
Product Details
| Supplier | US Biological | |
|---|---|---|
| Catalog #: | 213289-ML490-100UL (View supplier product page) | |
| Size | 100 μl | |
| Price | $865.00 | |
| Antigen | CD162 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | MaxLight 490 | |
| Target Species | Human | |
| Applications | IF, IHC, WB | |
| Description | SELPLG (P-Selectin Glycoprotein Ligand 1 Precursor, CLA, CD162, PSGL1, PSGL-1) (MaxLight 490) Pab |
About CD162 and MaxLight 490
| CD162 | This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011] | |
|---|---|---|
| MaxLight 490 | MaxLight 490 is excited by the 488 laser and emission captured by the 515/30 filter. It can be used with the following analysis platforms: Labeling, Flow Cytometry, Fluorescence Microscopy, Fluorescence Microscopy. |
Citations
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