CD158e Monoclonal / PE / DX9

Citations: (4)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-092-473 (View supplier product page)
Size 100 Tests in 1 ml
Price $320.00
Antigen CD158e
Clone DX9
Host Mouse
Isotype IgG1,Îșappa
Conjugate PE
Target Species Human
Applications FC
Description Clone DX9 recognizes CD158e (KIR3DL1), a member of the killer immunoglobulin-like receptor (KIR) family expressed on CD56dimCD16+ natural killer (NK) cells and CD8+ T cells. KIRs contribute to the regulation of NK cell-mediated cytotoxicity. They are monomeric receptors possessing high allelic polymorphism with either 2 or 3 Ig-like extracellular domains. According to the length of their cytoplasmic tail, KIRs can be further subdivided into inhibitory KIRs and activating KIRs (KIR2DS or KIR3DS). KIR3DL1 provides an inhibitory signal of NK cell lytic activity upon interaction with its specific ligand, HLA-Bw4.
Citations
PMID 9059894
PMID 11895890
PMID 12200350
PMID 12493005
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PE Excitation and Emission Spectra