FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-101-767 (View supplier product page)
	Size	100 Tests in 1 ml
	Price	$360.00
	Antigen	CD55
	Clone	JS11
	Host	Mouse
	Isotype	IgG1,κappa
	Conjugate	APC-Vio770
	Target Species	Human
	Applications	FC, MICS (MACSima Imaging Cyclic Staining), IF, IHC
	Description	Clone JS11 recognizes the CD55 antigen, a 70 kDa glycosylphosphatidylinositol-anchored single chain glycoprotein, which is also known as complement decay-accelerating factor (DAF). CD55 is broadly distributed among hematopoietic and non-hematopoietic cells. It is expressed on the plasma membranes of all cell types that are in intimate contact with serum and on the surfaces of epithelial cells lining the extracellular compartments. Variants of the molecule are present in body fluids and in extracellular matrix. CD55 plays multiple physiologic roles including tissue protection from the cytotoxic complement injury, anti-inflammatory function owing to its anti-adherence properties which enhance transmigration of monocytes and macrophages and reduce tissue injury. CD55 plays an essential role during pregnancy and is involved in the protection of the semiallogeneic fetus and in preventing uncontrolled infiltration by white cells. It is exploited in multiple pathologic conditions by pathogens and viruses in chronic tissue infection processes.

	CD55	This gene encodes a glycoprotein involved in the regulation of the complement cascade. Binding of the encoded protein to complement proteins accelerates their decay, thereby disrupting the cascade and preventing damage to host cells. Antigens present on this protein constitute the Cromer blood group system (CROM). Alternative splicing results in multiple transcript variants. The predominant transcript variant encodes a membrane-bound protein, but alternatively spliced transcripts may produce soluble proteins. [provided by RefSeq, Jul 2014]
	APC-Vio770	APC-Vio®770 from Miltenyi is a tandem fluorophore with APC as the donor and has an excitation peak at 652 nm and an emission peak at 775 nm, and is spectrally similar to APC-Cy® 7 (GE Healthcare) APC-H7 (BD Biosciences), APC-eFluor™ 780 (ThermoFisher Scientific), APC-Vio®770 (Miltenyi Biotec), and APC-Fire™ 750 (BioLegend). The Vio® dye family are products of Miltenyi Biotec, with many antibody conjugates designed and validated for flow cytometry.

$360.00
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CD55 Monoclonal / APC-Vio770 / JS11