FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-104-777 (View supplier product page)
	Size	9 μg in 30 μl
	Price	$90.00
	Antigen	CCR9
	Clone	CW-1.2
	Host	Mouse
	Isotype	IgG2a κ
	Conjugate	Vio Bright FITC
	Target Species	Mouse
	Applications	FC
	Description	The monoclonal antibody CW-1.2 recognizes mouse CD199, also known as CCR9. This chemokine receptor for TECK (CCL25) is a member of the G-protein coupled receptor (GPCR) family. The main function of GPCR family members is to send signals into the cell after the activation of G-proteins. It is reported that CCR9 influences T cell development at several stages within the thymus. Furthermore, in peripheral blood, CCR9 is expressed by naive CD8 T cells, but not by naive CD4 T cells.

	CCR9	The protein encoded by this gene is a G protein-coupled receptor with seven transmembrane domains that belongs to the beta chemokine receptor family. Chemokines and their receptors are key regulators of thymocyte migration and maturation in normal and inflammation conditions. This gene is differentially expressed in T lymphocytes of the small intestine and colon, and its interaction with chemokine 25 contributes to intestinal intra-epithelial lymphocyte homing to the small intestine. This suggests a role for this gene in directing immune responses to different segments of the gastrointestinal tract. This gene and its exclusive ligand, chemokine 25, are overexpressed in a variety of malignant tumors and are closely associated with tumor proliferation, apoptosis, invasion, migration and drug resistance. This gene maps to the chemokine receptor gene cluster. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2020]
	Vio Bright FITC	Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.

$90.00
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CCR9 Monoclonal / Vio Bright FITC / CW-1.2