CLA Monoclonal / PE / HECA-452
CLA Monoclonal / PE / HECA-452
Citations:
(3)
Product Details
| Supplier | Miltenyi Biotec | |
|---|---|---|
| Catalog #: | 130-091-635 (View supplier product page) | |
| Size | 100 Tests in 1 ml | |
| Price | $315.00 | |
| Antigen | CLA | |
| Clone | HECA-452 | |
| Host | Rat | |
| Isotype | IgM κ | |
| Conjugate | PE | |
| Target Species | Human | |
| Applications | MICS (MACSima Imaging Cyclic Staining), FC, IF, IHC | |
| Description | The Anti-CLA antibody recognizes the cutaneous lymphocyte-associated antigen (CLA), a specialized glycoform of P-selectin glycoprotein ligand-1 (PSGL-1). It serves as a ligand for selectins, including CD62E (ELAM-1) and CD62L (LECAM-1). CLA is a unique skin-homing receptor and is predominantly found on a minor subset of human T cells that infiltrate the skin. This post-translational modification of PSGL-1 is thought to serve as a mechanism to regulate tissue-specific homing of CD4+ and CD8+ memory/effector T cells from peripheral blood to the skin, which plays an essential role during many inflammatory and certain malignant skin diseases. | In peripheral blood, CLA is not only found on skin-homing memory/effector T cells, but is also found to be expressed on memory/effector B cells, NK cells, blood dendritic cells, and on monocytes. CLA is furthermore found on Langerhans cells in the skin. |
Citations
| PMID 7836740 | ||
|---|---|---|
| PMID 8342960 | ||
| PMID 9091586 | ||
| PMID 9353122 | ||
| PMID 10555994 | ||
| PMID 11086035 | ||
| PMID 14634085 | ||
| PMID 16803570 | ||
| Additional Sources |
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Reviews & Ratings
PE Excitation and Emission Spectra
$315.00
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