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	Supplier	Miltenyi Biotec
	Catalog #:	130-102-221 (View supplier product page)
	Size	30 μg in 1 ml
	Price	$95.00
	Antigen	L1CAM
	Clone	555
	Host	Rat
	Isotype	IgG2a
	Conjugate	APC
	Target Species	Mouse
	Applications	MICS (MACSima Imaging Cyclic Staining), FC, IF, IHC
	Description	The monoclonal antibody clone 555 recognizes CD171, a single pass type I membrane glycoprotein belonging to the immunoglobulin superfamily. Also known as L1CAM (L1 cell adhesion molecule) or NCAM-L1, CD171 belongs to a subgroup of cell adhesion molecules, which consists of six Ig-like domains, five fibronectin type III (FNIII)-like domains, a transmembrane region and a cytoplasmic domain. Expression of CD171 is found on tetanus-toxin positive neurons1, endothelial cells, certain epithelial cells, reticular fibroblasts and several malignant tumors including colon and breast carcinomas, colon melanoma, tumor cells of neuronal and mesothelial origin, where a role of CD171 in augmenting tumor growth has been demonstrated. Thus, CD171 is considered a novel marker for carcinoma progression. \| CD171 displays binding to a number of ligands including homophilic interaction with itself and heterophilic binding to integrins, other cell adhesion molecules, extracellular matrix molecules and thus plays a vital role in cell adhesion and signal transduction. It is involved in the development of the nervous system and regulates processes such as neuron–neuron adhesion, myelination, axonal guidance, and neuronal migration. \|

	L1CAM	The protein encoded by this gene is an axonal glycoprotein belonging to the immunoglobulin supergene family. The ectodomain, consisting of several immunoglobulin-like domains and fibronectin-like repeats (type III), is linked via a single transmembrane sequence to a conserved cytoplasmic domain. This cell adhesion molecule plays an important role in nervous system development, including neuronal migration and differentiation. Mutations in the gene cause X-linked neurological syndromes known as CRASH (corpus callosum hypoplasia, retardation, aphasia, spastic paraplegia and hydrocephalus). Alternative splicing of this gene results in multiple transcript variants, some of which include an alternate exon that is considered to be specific to neurons. [provided by RefSeq, May 2013]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

$95.00
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L1CAM Monoclonal / APC / 555