FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-106-321 (View supplier product page)
	Size	30 μg in 1 ml
	Price	$83.00
	Antigen	CD26
	Clone	H194-112
	Host	Rat
	Isotype	IgG2a κ
	Conjugate	APC
	Target Species	Mouse
	Applications	FC
	Description	Clone H194-112 recognizes the mouse CD26 antigen, a 220 kDa single-pass type II membrane protein also known as dipeptidyl peptidase 4 (Dpp4) or thymocyte-activating molecule (THAM). CD26 is a multifunctional glycoprotein expressed both as a soluble form in plasma and on the surface of several cell types, including epithelial and endothelial cells. In the immune system CD26 is expressed on thymocytes, activated T cells, B cells, NK cells, and macrophages. It has been involved in T cell costimulation, tumor suppression, and adenosine deaminase binding. In addition, CD26 is a serine protease belonging to a subgroup of prolyl oligopeptidases, whose members specifically cleave off N-terminal dipeptides from proteins having proline or alanine in amino acid position 2. The biological activity of several hormones and chemokines can be abolished by CD26 in vitro. Thus, CD26 has been implicated in the regulation of immune, inflammatory, nervous, and endocrine functions. \|

	CD26	The DPP4 gene encodes dipeptidyl peptidase 4, which is identical to adenosine deaminase complexing protein-2, and to the T-cell activation antigen CD26. It is an intrinsic type II transmembrane glycoprotein and a serine exopeptidase that cleaves X-proline dipeptides from the N-terminus of polypeptides. Dipeptidyl peptidase 4 is highly involved in glucose and insulin metabolism, as well as in immune regulation. This protein was shown to be a functional receptor for Middle East respiratory syndrome coronavirus (MERS-CoV), and protein modeling suggests that it may play a similar role with SARS-CoV-2, the virus responsible for COVID-19. [provided by RefSeq, Apr 2020]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

$83.00
Supplier Page

CD26 Monoclonal / APC / H194-112