FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-104-786 (View supplier product page)
	Size	30 tests in 300 µL
	Price	$100.00
	Antigen	CD263
	Clone	DJR3
	Host	Mouse
	Isotype	IgG1,κappa
	Conjugate	Biotin
	Target Species	Human
	Applications	FC
	Description	Clone DJR3 recognizes the human CD263 antigen, a glycophospholipid-anchored cell membrane protein which is also known as TNF-related apoptosis-inducing ligand receptor 3 (TRAIL-R3) or tumor necrosis factor receptor superfamily member 10C (TNFRSF10C). CD263 is the receptor for the cytotoxic ligand TRAIL. It lacks a cytoplasmic death domain shared by several members of the TNF receptor superfamily and hence is not capable of inducing apoptosis. CD263 is highly expressed in peripheral blood lymphocytes, spleen, skeletal muscle, placenta, lung, and heart. It is higher expressed in normal tissues than in tumor cell lines.

	CD263	The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008]

$100.00
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CD263 Monoclonal / Biotin / DJR3