FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-103-904 (View supplier product page)
	Size	30 tests in 300 µL
	Price	$145.00
	Antigen	CD111
	Clone	R1.302
	Host	Mouse
	Isotype	IgG1,κappa
	Conjugate	APC
	Target Species	Human
	Applications	FC
	Description	Clone R1.302 recognizes the CD111 antigen, a 75 kDa type I transmembrane glycoprotein also known as poliovirus receptor related 1 protein (PRR1), PVRL1, HveC, and Nectin-1. Nectins are involved in the formation of the mechanical adhesive puncta adherentia junctions of synapses. CD111 is an adhesion molecule that can be found in a wide range of tissues where it localizes in various junctions such as the adherens junction of epithelial tissue or the chemical synapse of neurons. In the chemical synapse, CD111 interacts with PVRL3 and both proteins can be found in neuronal tissue already in early stages of brain development as well as in aging brains. CD111 also functions as an entry receptor for herpes simplex virus and pseudorabies virus.

	CD111	This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

$145.00
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CD111 Monoclonal / APC / R1.302