FluoroFinder

	Supplier	US Biological
	Catalog #:	212659-APC-100UL (View supplier product page)
	Size	100 μl
	Price	$865.00
	Antigen	PML Protein
	Clone	14i52
	Host	Mouse
	Isotype	IgG
	Conjugate	APC
	Target Species	Mouse
	Applications	WB
	Description	PML (Promyelocytic Leukemia Protein, MYL, RNF71, PP8675, TRIM19) (APC) Mab 14i52

	PML Protein	The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This phosphoprotein localizes to nuclear bodies where it functions as a transcription factor and tumor suppressor. Its expression is cell-cycle related and it regulates the p53 response to oncogenic signals. The gene is often involved in the translocation with the retinoic acid receptor alpha gene associated with acute promyelocytic leukemia (APL). Extensive alternative splicing of this gene results in several variations of the protein's central and C-terminal regions; all variants encode the same N-terminus. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

	Additional Sources

PML Protein / APC / 14i52