GSAP / HRP /
GSAP / HRP /
Product Details
| Supplier | US Biological | |
|---|---|---|
| Catalog #: | 040075-HRP-200UL (View supplier product page) | |
| Size | 200 μl | |
| Price | $711.00 | |
| Antigen | GSAP | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | HRP | |
| Target Species | Human | |
| Applications | ELISA, IHC, WB | |
| Description | PION, CT (PION, GSAP, Gamma-secretase-activating protein, Protein pigeon homolog, Gamma-secretase-activating protein 16kD C-terminal form) (Azide free) (HRP) Pab |
About GSAP and HRP
| GSAP | Accumulation of neurotoxic amyloid-beta is a major hallmark of Alzheimer disease (AD; MIM 104300). Formation of amyloid-beta is catalyzed by gamma-secretase (see PSEN1; MIM 104311), a protease with numerous substrates. PION, or GSAP, selectively increases amyloid-beta production through a mechanism involving its interaction with both gamma-secretase and its substrate, the amyloid-beta precursor protein (APP; MIM 104760) C-terminal fragment (APP-CTF) (He et al., 2010 [PubMed 20811458]).[supplied by OMIM, Nov 2010] |
|---|
Citations
| Additional Sources |
|
|---|
