FluoroFinder

	Supplier	Miltenyi Biotec
	Catalog #:	130-104-672 (View supplier product page)
	Size	30 Tests in 300 μl
	Price	$79.00
	Antigen	CD100
	Clone	REA316
	Host	cell line
	Isotype	IgG1
	Conjugate	FITC
	Target Species	Human
	Applications	MICS (MACSima Imaging Cyclic Staining), IF, IHC, FC
	Description	Clone REA316 recognizes the human CD100 antigen, a single-pass type I membrane protein which is also known as semaphorin-4D (SEMA4D). CD100 is strongly expressed in skeletal muscle, and at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung, and pancreas. In the immune system, it is present on peripheral blood lymphocytes, spleen, and thymus, especially interfollicular T cells and B cells in the germinal centers of secondary lymphoid follicles. CD100 is an axon guidance molecule which is secreted by oligodendrocytes and induces growth cone collapse in the central nervous system. By binding plexin B1 receptor it functions as an R-Ras GTPase-activating protein and repels axon growth cones in the central nervous system. In the immune system, CD100 plays a critical role by turning off negative signaling by CD72 and significantly enhancing the effects of CD40 on B cell and dendritic cell responses. During skin damage repairs, SEMA4D interacts with plexin B2 on gamma delta T cells to play a role in the healing process. \| Additional information: Clone REA316 displays negligible binding to Fc receptors.

$79.00
Supplier Page

CD100 Monoclonal / FITC / REA316