CD25 / Vio Bright FITC / 4E3

Citations: (1)
Product Details
Supplier Miltenyi Biotec
Catalog #: 130-104-274 (View supplier product page)
Size 100 Tests
Price $345.00
Antigen CD25
Clone 4E3
Host Mouse
Isotype IgG2b κ
Conjugate Vio Bright FITC
Target Species Human, Non-Human Primate
Applications FC
Description Detection of activated human T and B cells and regulatory T cells, detection of CD25+ non-human primate cells
About CD25 and Vio Bright FITC
CD25 The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020]
Vio Bright FITC Vio®Bright FITC has an excitation peak at 496 nm and an emission peak at 522 nm. It is recommended for use in flow cytometry and fluorescence microscopy.
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Vio Bright FITC Excitation and Emission Spectra