P-Glycoprotein / MaxLight 405 /
P-Glycoprotein / MaxLight 405 /
Product Details
| Supplier | US Biological | |
|---|---|---|
| Catalog #: | 039557-ML405-100UL (View supplier product page) | |
| Size | 100 μl | |
| Price | $711.00 | |
| Antigen | P-Glycoprotein | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | MaxLight 405 | |
| Target Species | Human | |
| Applications | WB | |
| Description | P-Glycoprotein, ID (ABCB1, MDR1, PGY1, Multidrug resistance protein 1, ATP-binding cassette sub-family B member 1, P-glycoprotein 1, CD243) (MaxLight 405) Pab |
About P-Glycoprotein and MaxLight 405
| P-Glycoprotein | The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is an ATP-dependent drug efflux pump for xenobiotic compounds with broad substrate specificity. It is responsible for decreased drug accumulation in multidrug-resistant cells and often mediates the development of resistance to anticancer drugs. This protein also functions as a transporter in the blood-brain barrier. Mutations in this gene are associated with colchicine resistance and Inflammatory bowel disease 13. Alternative splicing and the use of alternative promoters results in multiple transcript variants. [provided by RefSeq, Feb 2017] | |
|---|---|---|
| MaxLight 405 | MaxLight 405 is excited by the 405 laser and emission captured by the 450/50 filter. It can be used with the following analysis platforms: Labeling, Flow Cytometry, Fluorescence Microscopy, Fluorescence Microscopy. |
Citations
| Additional Sources |
|
|---|
