FluoroFinder

	Supplier	US Biological
	Catalog #:	M4700-06P-APC-100UL (View supplier product page)
	Size	100 μl
	Price	$888.00
	Antigen	MUC-1
	Clone	10J41
	Host	Mouse
	Isotype	IgG
	Conjugate	APC
	Target Species	Human
	Applications	IHC
	Description	Mucin 1 (Mucin-1, MUC1, MUC-1, Breast Carcinoma-associated Antigen DF3, Carcinoma Associated Mucin, CD227, DF3, Episialin, Epithelial Membrane Antigen, EMA, H23 Antigen, H23AG, HGNC:7508, KL-6, MAM6, Peanut-reactive Urinary Mucin, PUM, Polymorphic Epithelial Mucin, PEM, PEMT, Tumor Associated Epithelial Membrane Antigen, Tumor-associated Mucin) (APC) Mab 10J41

	MUC-1	This gene encodes a membrane-bound protein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. This protein is expressed on the apical surface of epithelial cells that line the mucosal surfaces of many different tissues including lung, breast stomach and pancreas. This protein is proteolytically cleaved into alpha and beta subunits that form a heterodimeric complex. The N-terminal alpha subunit functions in cell-adhesion and the C-terminal beta subunit is involved in cell signaling. Overexpression, aberrant intracellular localization, and changes in glycosylation of this protein have been associated with carcinomas. This gene is known to contain a highly polymorphic variable number tandem repeats (VNTR) domain. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Feb 2011]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

	Additional Sources

MUC-1 / APC / 10J41