MSR1 / APC / 2G9
MSR1 / APC / 2G9
Product Details
| Supplier | US Biological | |
|---|---|---|
| Catalog #: | 248963-APC-100UL (View supplier product page) | |
| Size | 100 μl | |
| Price | $681.00 | |
| Antigen | MSR1 | |
| Clone | 2G9 | |
| Host | Mouse | |
| Isotype | IgG3 κ | |
| Conjugate | APC | |
| Target Species | Human | |
| Applications | ELISA, WB | |
| Description | MSR1 (macrophage scavenger Receptor 1, CD204, SCARA1, SR-A, phSR1, phSR2) (APC) Mab 2G9 |
About MSR1 and APC
| MSR1 | This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008] | |
|---|---|---|
| APC | Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm. |
Citations
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