FluoroFinder

	Supplier	US Biological
	Catalog #:	M1210-04K-100TESTS (View supplier product page)
	Size	100 Tests
	Price	$706.00
	Antigen	MSR1
	Clone	11C38
	Host	Rat
	Isotype	IgG2b
	Conjugate	APC
	Target Species	Mouse
	Applications	FC
	Description	MSR1 (Macrophage Scavenger Receptor Types I and II, Macrophage Acetylated LDL Receptor I and II, Scavenger Receptor Type A, SR-A, CD204, Scvr) (APC) Mab 11C38

	MSR1	This gene encodes the class A macrophage scavenger receptors, which include three different types (1, 2, 3) generated by alternative splicing of this gene. These receptors or isoforms are macrophage-specific trimeric integral membrane glycoproteins and have been implicated in many macrophage-associated physiological and pathological processes including atherosclerosis, Alzheimer's disease, and host defense. The isoforms type 1 and type 2 are functional receptors and are able to mediate the endocytosis of modified low density lipoproteins (LDLs). The isoform type 3 does not internalize modified LDL (acetyl-LDL) despite having the domain shown to mediate this function in the types 1 and 2 isoforms. It has an altered intracellular processing and is trapped within the endoplasmic reticulum, making it unable to perform endocytosis. The isoform type 3 can inhibit the function of isoforms type 1 and type 2 when co-expressed, indicating a dominant negative effect and suggesting a mechanism for regulation of scavenger receptor activity in macrophages. [provided by RefSeq, Jul 2008]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

	Additional Sources

MSR1 / APC / 11C38