MLKL / Biotin / 3B2
MLKL / Biotin / 3B2
Product Details
| Supplier | US Biological | |
|---|---|---|
| Catalog #: | 129722-Biotin-100UL (View supplier product page) | |
| Size | 100 μl | |
| Price | $681.00 | |
| Antigen | MLKL | |
| Clone | 3B2 | |
| Host | Mouse | |
| Isotype | IgG2a κ | |
| Conjugate | Biotin | |
| Target Species | Human | |
| Applications | ELISA, IF, IHC, WB | |
| Description | MLKL (Mixed Lineage Kinase Domain-like Protein, FLJ34389) (Biotin) Mab 3B2 |
About MLKL and Biotin
| MLKL | This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015] |
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Citations
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