LIM kinase 2 / APC /
LIM kinase 2 / APC /
Product Details
| Supplier | US Biological | |
|---|---|---|
| Catalog #: | 211768-APC-100UL (View supplier product page) | |
| Size | 100 μl | |
| Price | $865.00 | |
| Antigen | LIM kinase 2 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | APC | |
| Target Species | Human | |
| Applications | IHC, WB | |
| Description | LIMK2 (LIM Domain Kinase 2, LIMK-2) (APC) Pab |
About LIM kinase 2 and APC
| LIM kinase 2 | There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. The protein encoded by this gene is phosphorylated and activated by ROCK, a downstream effector of Rho, and the encoded protein, in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity. It is thought that this pathway contributes to Rho-induced reorganization of the actin cytoskeleton. At least three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] | |
|---|---|---|
| APC | Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm. |
Citations
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