CD25 / APC-Alexa 700 / B1.49.9
CD25 / APC-Alexa 700 / B1.49.9
Citations:
(1)
Product Details
| Supplier | Beckman Coulter | |
|---|---|---|
| Catalog #: | A86356 (View supplier product page) | |
| Size | 0.5 mL | |
| Price | ||
| Antigen | CD25 | |
| Clone | B1.49.9 | |
| Host | Mouse | |
| Isotype | IgG2a | |
| Conjugate | APC-Alexa 700 | |
| Target Species | Human | |
| Applications | Activation, Cell Labeling | |
| Description | CD25-APC-A700, B1.49.9, 0.5 mL, ASR |
About CD25 and APC-Alexa 700
| CD25 | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020] | |
|---|---|---|
| APC-Alexa 700 | APC-Alexa 700 from Thermo Fisher Scientific has an excitation peak at 651 nm and an emission peak at 719 nm and is most commonly used in flow cytometry. |
Citations
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