PD-1 / Alexa Fluor 488 / EH12.2H7
PD-1 / Alexa Fluor 488 / EH12.2H7
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 329935 (View supplier product page) | |
| Size | 25T | |
| Price | $147.00 | |
| Antigen | PD-1 | |
| Clone | EH12.2H7 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | Alexa Fluor 488 | |
| Target Species | Human | |
| Applications | FC | |
| Description | Alexa Fluor 488 anti-human CD279 (PD-1) |
About PD-1 and Alexa Fluor 488
| PD-1 | Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020] | |
|---|---|---|
| Alexa Fluor 488 | Alexa Fluor™ 488 (AF488, Alexa 488) has an excitation peak at 488 nm and an emission peak at 496 nm, and is considered a high-performance alternative to FITC. Alexa 488 is one of the most popular Alexa Fluor™ dyes and is widely used in Fluorescence Microscopy, flow cytometry, and for staining low expression markers. It is bright, highly photostable, resistant to pH changes, and less susceptible to photobleaching. Alexa 488 and is similar in size, brightness and application to DyLight™ 488, iFluor® 488 and CF®488A. |
Images
|
PHA-stimulated (day 3) human peripheral blood lymphocytes were stained with CD279 (clone EH12.2H7) Alexa Fluor® 488 (filled histogram) or mouse IgG1, κ Alexa Fluor® 488 isotype control (open histogram). |
Citations
| PMID 18829748 | ||
|---|---|---|
| PMID 18981087 | ||
| PMID 19553327 | ||
| PMID 19889785 | ||
| PMID 20100932 | ||
| PMID 21398606 | ||
| PMID 21562156 | ||
| Additional Sources |
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Reviews & Ratings
Alexa Fluor 488 Excitation and Emission Spectra
$147.00
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