PD-1 / APC-Cy7 / 29F.1A12

Citations: (19)
Product Details
Supplier BioLegend
Catalog #: 135223 (View supplier product page)
Size 25 μg
Price $141.00
Antigen PD-1
Clone 29F.1A12
Host Rat
Isotype IgG2a κ
Conjugate APC-Cy7
Target Species Mouse
Applications FC
Description APC/Cyanine7 anti-mouse CD279 (PD-1)
About PD-1 and APC-Cy7
PD-1 Programmed cell death protein 1 (PDCD1) is an immune-inhibitory receptor expressed in activated T cells; it is involved in the regulation of T-cell functions, including those of effector CD8+ T cells. In addition, this protein can also promote the differentiation of CD4+ T cells into T regulatory cells. PDCD1 is expressed in many types of tumors including melanomas, and has demonstrated to play a role in anti-tumor immunity. Moreover, this protein has been shown to be involved in safeguarding against autoimmunity, however, it can also contribute to the inhibition of effective anti-tumor and anti-microbial immunity. [provided by RefSeq, Aug 2020]
APC-Cy7 APC-Cy7 (APC-Cyanine 7) has an excitation peak at 650 nm and an emission peak at 785 nm, and is spectrally similar to APC-CF®750 (Biotium), APC-H7 (BD Biosciences), APC-eFluor™ 780 (Thermo Fisher Scientific), APC-Vio®770 (Miltenyi Biotec) and APC-Fire™ 750 (BioLegend). This dye is a member of the Cyanine® dye family, a trademark of GE heathcare.
Images
  PD-1 APC-Cy7 BioLegend antibody anti target:Mouse host:Rat isotype:IgG2a κ clone:29F.1A12

Con-A stimulated splenocytes (3 days) were stained with CD3 Brilliant Violet 421™ and CD279 (clone 29F1.A12, top) APC/Cy7 or rat IgG2a, κ APC/Cy7 isotype control (bottom).

  PD-1 APC-Cy7 BioLegend antibody anti target:Mouse host:Rat isotype:IgG2a κ clone:29F.1A12

Citations
PMID 20453843
Additional
Sources
Reviews & Ratings
APC-Cy7 Excitation and Emission Spectra