Ikaros / PE / D6N9Y
Ikaros / PE / D6N9Y
Product Details
| Supplier | US Biological | |
|---|---|---|
| Catalog #: | 351836-100UL (View supplier product page) | |
| Size | 100 μl | |
| Price | $568.00 | |
| Antigen | Ikaros | |
| Clone | D6N9Y | |
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | PE | |
| Target Species | Human | |
| Applications | FC | |
| Description | Ikaros (IKZF1, LYF1, DNA-Binding Protein Ikaros) (PE) Mab D6N9Y |
About Ikaros and PE
| Ikaros | This gene encodes a transcription factor that belongs to the family of zinc-finger DNA-binding proteins associated with chromatin remodeling. The expression of this protein is restricted to the fetal and adult hemo-lymphopoietic system, and it functions as a regulator of lymphocyte differentiation. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. Most isoforms share a common C-terminal domain, which contains two zinc finger motifs that are required for hetero- or homo-dimerization, and for interactions with other proteins. The isoforms, however, differ in the number of N-terminal zinc finger motifs that bind DNA and in nuclear localization signal presence, resulting in members with and without DNA-binding properties. Only a few isoforms contain the requisite three or more N-terminal zinc motifs that confer high affinity binding to a specific core DNA sequence element in the promoters of target genes. The non-DNA-binding isoforms are largely found in the cytoplasm, and are thought to function as dominant-negative factors. Overexpression of some dominant-negative isoforms have been associated with B-cell malignancies, such as acute lymphoblastic leukemia (ALL). [provided by RefSeq, May 2014] | |
|---|---|---|
| PE | Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts. |
Citations
| Additional Sources |
|
|---|
