CD25 / Brilliant Violet 510 / PC61
CD25 / Brilliant Violet 510 / PC61
Citations:
(17)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 102041 (View supplier product page) | |
| Size | 125UL | |
| Price | $193.00 | |
| Antigen | CD25 | |
| Clone | PC61 | |
| Host | Rat | |
| Isotype | IgG1 λ | |
| Conjugate | Brilliant Violet 510 | |
| Target Species | Mouse | |
| Applications | FC | |
| Description | Brilliant Violet 510 anti-mouse CD25 |
About CD25 and Brilliant Violet 510
| CD25 | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020] | |
|---|---|---|
| Brilliant Violet 510 | Brilliant™ Violet 510 (BV510) is a green-emitting non-tandem polymer fluorophore that can be excited by the 405 nm Violet laser and collected using a 510/50 bandpass filter. BV510 has an excitation peak at 405 nm and an emission peak at 510 nm, and is similar to StarBright Violet 515 (Bio-Rad). BV510 is most often used in flow cytometry due to its improved signal-to-noise over alternatives like V500 and AmCyan. This dye is part of the Brilliant™ Violet dye line. BV510 and BV480 are the only dyes in the Brilliant™ Violet dye family that are not tandem fluorophores based off the BV421 polymer core, but they have nearly the same maximum excitation. |
Images
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Con A-stimulated (3 days) Balb/c splenocytes were stained with CD25 (clone PC61) Brilliant Violet 510™ (filled histogram). Unstained control cells are represented by the open histogram. |
Citations
| PMID 23099863 | ||
|---|---|---|
| Additional Sources |
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Reviews & Ratings
Brilliant Violet 510 Excitation and Emission Spectra
$193.00
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