CD117 / Alexa Fluor 488 / ACK2
CD117 / Alexa Fluor 488 / ACK2
Citations:
(1)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 135118 (View supplier product page) | |
| Size | 100 μg | |
| Price | $229.00 | |
| Antigen | CD117 | |
| Clone | ACK2 | |
| Host | Rat | |
| Isotype | IgG2b κ | |
| Conjugate | Alexa Fluor 488 | |
| Target Species | Mouse | |
| Applications | FC | |
| Description | Alexa Fluor 488 anti-mouse CD117 (c-kit) |
About CD117 and Alexa Fluor 488
| CD117 | This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020] | |
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| Alexa Fluor 488 | Alexa Fluor™ 488 (AF488, Alexa 488) has an excitation peak at 488 nm and an emission peak at 496 nm, and is considered a high-performance alternative to FITC. Alexa 488 is one of the most popular Alexa Fluor™ dyes and is widely used in Fluorescence Microscopy, flow cytometry, and for staining low expression markers. It is bright, highly photostable, resistant to pH changes, and less susceptible to photobleaching. Alexa 488 and is similar in size, brightness and application to DyLight™ 488, iFluor® 488 and CF®488A. |
Images
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C57BL/6 mouse bone marrow cells were stained with CD11b APC and CD117 (clone ACK2) Alexa Fluor® 488 (top) or rat IgG2b, κ Alexa Fluor® 488 isotype control (bottom). Data shown was gated on total bone marrow cells. |
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Citations
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Reviews & Ratings
Alexa Fluor 488 Excitation and Emission Spectra
$229.00
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