CD40 / Pacific Blue / 3/23
CD40 / Pacific Blue / 3/23
Citations:
(7)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 124626 (View supplier product page) | |
| Size | 100 μg | |
| Price | $293.00 | |
| Antigen | CD40 | |
| Clone | 3/23 | |
| Host | Rat | |
| Isotype | IgG2a κ | |
| Conjugate | Pacific Blue | |
| Target Species | Mouse | |
| Applications | FC | |
| Description | Pacific Blue anti-mouse CD40 |
About CD40 and Pacific Blue
| CD40 | This gene is a member of the TNF-receptor superfamily. The encoded protein is a receptor on antigen-presenting cells of the immune system and is essential for mediating a broad variety of immune and inflammatory responses including T cell-dependent immunoglobulin class switching, memory B cell development, and germinal center formation. AT-hook transcription factor AKNA is reported to coordinately regulate the expression of this receptor and its ligand, which may be important for homotypic cell interactions. Adaptor protein TNFR2 interacts with this receptor and serves as a mediator of the signal transduction. The interaction of this receptor and its ligand is found to be necessary for amyloid-beta-induced microglial activation, and thus is thought to be an early event in Alzheimer disease pathogenesis. Mutations affecting this gene are the cause of autosomal recessive hyper-IgM immunodeficiency type 3 (HIGM3). Multiple alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Nov 2014] | |
|---|---|---|
| Pacific Blue | Pacific Blue® (Pac Blue, PacBlue) is a blue-emitting organic fluorophore that can be excited by the 405 nm Violet laser and captured with a 450/50 nm bandpass filter. Pacific Blue has an excititaion peak at 401 nm and an emission peak at 452 nm. |
Images
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C57BL/6 mouse splenocytes were stained with CD40 (clone 3/23) Pacific Blue™ (filled histogram) or rat IgG2a, κ Pacific Blue™ isotype control (open histogram). |
Citations
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Reviews & Ratings
Pacific Blue Excitation and Emission Spectra
$293.00
Supplier Page
Supplier Page
