CD45 / Brilliant Violet 510 / HI30
CD45 / Brilliant Violet 510 / HI30
Citations:
(16)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 304035 (View supplier product page) | |
| Size | 25T | |
| Price | $198.00 | |
| Antigen | CD45 | |
| Clone | HI30 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | Brilliant Violet 510 | |
| Target Species | Human | |
| Applications | FC | |
| Description | Brilliant Violet 510 anti-human CD45 |
About CD45 and Brilliant Violet 510
| CD45 | The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitosis, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and two tandem intracytoplasmic catalytic domains, and thus is classified as a receptor type PTP. This PTP has been shown to be an essential regulator of T- and B-cell antigen receptor signaling. It functions through either direct interaction with components of the antigen receptor complexes, or by activating various Src family kinases required for the antigen receptor signaling. This PTP also suppresses JAK kinases, and thus functions as a regulator of cytokine receptor signaling. Alternatively spliced transcripts variants of this gene, which encode distinct isoforms, have been reported. [provided by RefSeq, Jun 2012] | |
|---|---|---|
| Brilliant Violet 510 | Brilliant™ Violet 510 (BV510) is a green-emitting non-tandem polymer fluorophore that can be excited by the 405 nm Violet laser and collected using a 510/50 bandpass filter. BV510 has an excitation peak at 405 nm and an emission peak at 510 nm, and is similar to StarBright Violet 515 (Bio-Rad). BV510 is most often used in flow cytometry due to its improved signal-to-noise over alternatives like V500 and AmCyan. This dye is part of the Brilliant™ Violet dye line. BV510 and BV480 are the only dyes in the Brilliant™ Violet dye family that are not tandem fluorophores based off the BV421 polymer core, but they have nearly the same maximum excitation. |
Images
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Human peripheral blood lymphocytes were stained with CD45 (clone HI30) Brilliant Violet 510™. |
Citations
| PMID 18544681 | ||
|---|---|---|
| PMID 21138865 | ||
| PMID 22828869 | ||
| PMID 24648400 | ||
| PMID 25672754 | ||
| PMID 25687281 | ||
| PMID 25687283 | ||
| Additional Sources |
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Reviews & Ratings
Brilliant Violet 510 Excitation and Emission Spectra
$198.00
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