FluoroFinder

	Supplier	US Biological
	Catalog #:	168793-AF-Biotin-100UL (View supplier product page)
	Size	100 μl
	Price	$694.00
	Antigen	ErbB2
	Clone	HRB2/718
	Host	Mouse
	Isotype	IgG1 κ
	Conjugate	Biotin
	Target Species	Human
	Applications	IF, IHC, IP
	Description	HER-2 (p185, CD340, Verb b2 Erythroblastic Leukemia Viral Oncogene Homolog 2, Neuro/Glioblastoma Derived Oncogene Homolog) (Biotin) Mab HRB2/718

	ErbB2	This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008]

	Additional Sources

ErbB2 / Biotin / HRB2/718