FluoroFinder

	Supplier	US Biological
	Catalog #:	125217-FITC-100UL (View supplier product page)
	Size	100 μl
	Price	$681.00
	Antigen	GJB3
	Clone	3B4-1B3
	Host	Mouse
	Isotype	IgG1 κ
	Conjugate	FITC
	Target Species	Human
	Applications	ELISA, IF, WB
	Description	Connexin 31 (Connexin-31, CX31, DFNA2, DFNA2B, EKV, FLJ22486, Gap Junction Beta 3 Protein, Gap Junction Protein beta 3 31kDa, GJB3, MGC102938) (FITC) Mab 3B4-1B3

	GJB3	This gene is a member of the connexin gene family. The encoded protein is a component of gap junctions, which are composed of arrays of intercellular channels that provide a route for the diffusion of low molecular weight materials from cell to cell. Mutations in this gene can cause non-syndromic deafness or erythrokeratodermia variabilis, a skin disorder. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]
	FITC	Fluorescein isothiocyanate (FITC) has an excitation peak at 495 nm and an emission peak at 519 nm. The name FITC is a misnomer in that the isothiocyanate is a reactive form of this dye. Once FITC is conjugated to an antibody, it is simply Fluorescein conjugated. FITC is one of the most widely used dyes for fluorescent applications, therefore most instruments come standard with a 488 nm laser and FITC filter set up. FITC is commonly conjugated to secondary antibodies and used in applications such as flow cytometry, immunocytochemistry, and immunohistochemistry. FITC is relatively dim, sensitive to photobleaching and it is susceptible to changes is pH. There are better performing alternatives to FITC, like Vio®Bright 515, Alexa Fluor™ 488, iFluor® 488, CF®488A and DY-488. FITC is a long-time generic dye with no sole manufacturer or trademark.

	Additional Sources

GJB3 / FITC / 3B4-1B3