CD25 / APC / 3C7
CD25 / APC / 3C7
Citations:
(52)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 101910 (View supplier product page) | |
| Size | 100 μg | |
| Price | $297.00 | |
| Antigen | CD25 | |
| Clone | 3C7 | |
| Host | Rat | |
| Isotype | IgG2b κ | |
| Conjugate | APC | |
| Target Species | Mouse | |
| Applications | FC | |
| Description | APC anti-mouse CD25 |
About CD25 and APC
| CD25 | The interleukin 2 (IL2) receptor alpha (IL2RA) and beta (IL2RB) chains, together with the common gamma chain (IL2RG), constitute the high-affinity IL2 receptor. Homodimeric alpha chains (IL2RA) result in low-affinity receptor, while homodimeric beta (IL2RB) chains produce a medium-affinity receptor. Normally an integral-membrane protein, soluble IL2RA has been isolated and determined to result from extracellular proteolyisis. Alternately-spliced IL2RA mRNAs have been isolated, but the significance of each is presently unknown. Mutations in this gene are associated with interleukin 2 receptor alpha deficiency. Patients with severe Coronavirus Disease 2019 (COVID-19), the disease caused by the novel severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), have significantly elevated levels of IL2R in their plasma. Similarly, serum IL-2R levels are found to be elevated in patients with different types of carcinomas. Certain IL2RA and IL2RB gene polymorphisms have been associated with lung cancer risk. [provided by RefSeq, Jul 2020] | |
|---|---|---|
| APC | Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm. |
Images
|
ConA/IL-2 stimulated (3 days) C57BL/6 splenocytes were stained with CD25 (clone 3C7) APC (filled histogram) or rat IgG2b, κ APC isotype control (open histogram). |
Citations
| PMID 22021618 | ||
|---|---|---|
| PMID 23182710 | ||
| Additional Sources |
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Reviews & Ratings
APC Excitation and Emission Spectra
$297.00
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