FluoroFinder

	Supplier	US Biological
	Catalog #:	E3451-35DX-Biotin-100UL (View supplier product page)
	Size	100 μl
	Price	$921.00
	Antigen	ErbB3
	Clone	3F164, 2B5
	Host	Mouse
	Isotype	IgG1
	Conjugate	Biotin
	Target Species	Rat
	Applications	IP, WB
	Description	ErbB3 (ERBB3, v-erb-b2 Erythroblastic Leukemia Viral Oncogene Homolog 3 avian, HGNC:3431, ErbB-3, HER3, MDA-BF-1, c-erbB-3, c-erbB3, erbB3-S, p180-ErbB3, p45-sErbB3) (BSA & Azide Free) (Biotin) Mab 3F164, 2B5

	ErbB3	This gene encodes a member of the epidermal growth factor receptor (EGFR) family of receptor tyrosine kinases. This membrane-bound protein has a neuregulin binding domain but not an active kinase domain. It therefore can bind this ligand but not convey the signal into the cell through protein phosphorylation. However, it does form heterodimers with other EGF receptor family members which do have kinase activity. Heterodimerization leads to the activation of pathways which lead to cell proliferation or differentiation. Amplification of this gene and/or overexpression of its protein have been reported in numerous cancers, including prostate, bladder, and breast tumors. Alternate transcriptional splice variants encoding different isoforms have been characterized. One isoform lacks the intermembrane region and is secreted outside the cell. This form acts to modulate the activity of the membrane-bound form. Additional splice variants have also been reported, but they have not been thoroughly characterized. [provided by RefSeq, Jul 2008]

	Additional Sources

ErbB3 / Biotin / 3F164, 2B5