ErbB2 / MaxLight 405 /
ErbB2 / MaxLight 405 /
Product Details
| Supplier | US Biological | |
|---|---|---|
| Catalog #: | E3451-26G-ML405-100UL (View supplier product page) | |
| Size | 100 μl | |
| Price | $711.00 | |
| Antigen | ErbB2 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | MaxLight 405 | |
| Target Species | Human | |
| Applications | ELISA, IHC, WB | |
| Description | ErbB2 (Tyr1248) (Receptor Tyrosine-protein Kinase erbB-2, p185erbB2, Proto-oncogene C-erbB-2, Proto-oncogene NEU, Tyrosine Kinase-type Cell Surface Receptor HER2, Metastatic Lymph Node Gene 19 Protein MLN 19, HER2, NEU, NGL) (MaxLight 405) Pab |
About ErbB2 and MaxLight 405
| ErbB2 | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] | |
|---|---|---|
| MaxLight 405 | MaxLight 405 is excited by the 405 laser and emission captured by the 450/50 filter. It can be used with the following analysis platforms: Labeling, Flow Cytometry, Fluorescence Microscopy, Fluorescence Microscopy. |
Citations
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