CD117 / Brilliant Violet 510 / 104D2
CD117 / Brilliant Violet 510 / 104D2
Citations:
(4)
Product Details
| Supplier | BioLegend | |
|---|---|---|
| Catalog #: | 313220 (View supplier product page) | |
| Size | 100T | |
| Price | $435.00 | |
| Antigen | CD117 | |
| Clone | 104D2 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | Brilliant Violet 510 | |
| Target Species | Human | |
| Applications | FC | |
| Description | Brilliant Violet 510 anti-human CD117 (c-kit) |
About CD117 and Brilliant Violet 510
| CD117 | This gene encodes a receptor tyrosine kinase. This gene was initially identified as a homolog of the feline sarcoma viral oncogene v-kit and is often referred to as proto-oncogene c-Kit. The canonical form of this glycosylated transmembrane protein has an N-terminal extracellular region with five immunoglobulin-like domains, a transmembrane region, and an intracellular tyrosine kinase domain at the C-terminus. Upon activation by its cytokine ligand, stem cell factor (SCF), this protein phosphorylates multiple intracellular proteins that play a role in in the proliferation, differentiation, migration and apoptosis of many cell types and thereby plays an important role in hematopoiesis, stem cell maintenance, gametogenesis, melanogenesis, and in mast cell development, migration and function. This protein can be a membrane-bound or soluble protein. Mutations in this gene are associated with gastrointestinal stromal tumors, mast cell disease, acute myelogenous leukemia, and piebaldism. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2020] | |
|---|---|---|
| Brilliant Violet 510 | Brilliant™ Violet 510 (BV510) is a green-emitting non-tandem polymer fluorophore that can be excited by the 405 nm Violet laser and collected using a 510/50 bandpass filter. BV510 has an excitation peak at 405 nm and an emission peak at 510 nm, and is similar to StarBright Violet 515 (Bio-Rad). BV510 is most often used in flow cytometry due to its improved signal-to-noise over alternatives like V500 and AmCyan. This dye is part of the Brilliant™ Violet dye line. BV510 and BV480 are the only dyes in the Brilliant™ Violet dye family that are not tandem fluorophores based off the BV421 polymer core, but they have nearly the same maximum excitation. |
Images
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Human erythroleukemia cell line (HEL) was stained with CD117 (clone 104D2) Brilliant Violet 510™ (filled histogram) or mouse IgG1, κ Brilliant Violet 510™ isotype control (open histogram). |
Citations
| PMID 17379743 | ||
|---|---|---|
| Additional Sources |
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Reviews & Ratings
Brilliant Violet 510 Excitation and Emission Spectra
$435.00
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