DUSP3 / PE /
DUSP3 / PE /
Product Details
| Supplier | US Biological | |
|---|---|---|
| Catalog #: | D9840-06C-PE-200UL (View supplier product page) | |
| Size | 200 μl | |
| Price | $711.00 | |
| Antigen | DUSP3 | |
| Clone | ||
| Host | Rabbit | |
| Isotype | IgG | |
| Conjugate | PE | |
| Target Species | Human | |
| Applications | ELISA, IHC, WB | |
| Description | DUSP3, NT (Dual Specificity Protein Phosphatase 3, Dual Specificity Protein Phosphatase VHR, VHR) (PE) Pab |
About DUSP3 and PE
| DUSP3 | The protein encoded by this gene is a member of the dual specificity protein phosphatase subfamily. These phosphatases inactivate their target kinases by dephosphorylating both the phosphoserine/threonine and phosphotyrosine residues. They negatively regulate members of the mitogen-activated protein (MAP) kinase superfamily (MAPK/ERK, SAPK/JNK, p38), which are associated with cellular proliferation and differentiation. Different members of the family of dual specificity phosphatases show distinct substrate specificities for various MAP kinases, different tissue distribution and subcellular localization, and different modes of inducibility of their expression by extracellular stimuli. This gene maps in a region that contains the BRCA1 locus which confers susceptibility to breast and ovarian cancer. Although DUSP3 is expressed in both breast and ovarian tissues, mutation screening in breast cancer pedigrees and in sporadic tumors was negative, leading to the conclusion that this gene is not BRCA1. [provided by RefSeq, Jul 2008] | |
|---|---|---|
| PE | Phycoerythrin (PE, R-PE) is a red-emitting fluorescent protein-chromophore complex that can be excited the 488-nm blue, 532-nm green, or 561-nm yellow-green laser with increasing efficiency and captured with a 586/14 nm bandpass filter. PE has an excitation peak at 565 nm and an emission peak at 578 nm. PE is 240kD in size and has an extinction coefficient of ~2x10^6 which makes it one of the brightest fluorophores available and a potent donor upon which to build tandem fluorophores with longer Stoke's Shifts. |
Citations
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