CD263 / FITC / 2B8
CD263 / FITC / 2B8
Product Details
| Supplier | US Biological | |
|---|---|---|
| Catalog #: | D1499-01A4-100UG (View supplier product page) | |
| Size | 100 μg | |
| Price | $553.00 | |
| Antigen | CD263 | |
| Clone | 2B8 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | FITC | |
| Target Species | Human | |
| Applications | FC | |
| Description | DcR1 (Decoy Receptor 1, CD263, Lymphocyte Inhibitor of TRAIL, LIT, TNF Related Apoptosis Inducing Ligand Receptor 3, TRAIL Receptor 3, TRAIL R3, TRAILR3, TRAIL-R3, TRAIL Receptor Without An Intracellular Domain, TRID, Tumor Necrosis Factor Receptor Superfamily Member 10C, TNFRSF10C) (FITC) Mab 2B8 |
About CD263 and FITC
| CD263 | The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor contains an extracellular TRAIL-binding domain and a transmembrane domain, but no cytoplasmic death domain. This receptor is not capable of inducing apoptosis, and is thought to function as an antagonistic receptor that protects cells from TRAIL-induced apoptosis. This gene was found to be a p53-regulated DNA damage-inducible gene. The expression of this gene was detected in many normal tissues but not in most cancer cell lines, which may explain the specific sensitivity of cancer cells to the apoptosis-inducing activity of TRAIL. [provided by RefSeq, Jul 2008] | |
|---|---|---|
| FITC | Fluorescein isothiocyanate (FITC) has an excitation peak at 495 nm and an emission peak at 519 nm. The name FITC is a misnomer in that the isothiocyanate is a reactive form of this dye. Once FITC is conjugated to an antibody, it is simply Fluorescein conjugated. FITC is one of the most widely used dyes for fluorescent applications, therefore most instruments come standard with a 488 nm laser and FITC filter set up. FITC is commonly conjugated to secondary antibodies and used in applications such as flow cytometry, immunocytochemistry, and immunohistochemistry. FITC is relatively dim, sensitive to photobleaching and it is susceptible to changes is pH. There are better performing alternatives to FITC, like Vio®Bright 515, Alexa Fluor™ 488, iFluor® 488, CF®488A and DY-488. FITC is a long-time generic dye with no sole manufacturer or trademark. |
Citations
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