ErbB2 / MaxLight 650 / ICR55
ErbB2 / MaxLight 650 / ICR55
Product Details
| Supplier | US Biological | |
|---|---|---|
| Catalog #: | C0026-15G-ML650-100UL (View supplier product page) | |
| Size | 100 μl | |
| Price | $788.00 | |
| Antigen | ErbB2 | |
| Clone | ICR55 | |
| Host | Rat | |
| Isotype | IgG2a | |
| Conjugate | MaxLight 650 | |
| Target Species | Human | |
| Applications | IHC, IP, WB | |
| Description | c-erbB2 (HER-2, neu Receptor) (MaxLight 650) Mab ICR55 |
About ErbB2 and MaxLight 650
| ErbB2 | This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized. [provided by RefSeq, Jul 2008] | |
|---|---|---|
| MaxLight 650 | MaxLight 650 is excited by the 640 laser and emission captured by the 670/30 filter. It can be used with the following analysis platforms: Labeling, Flow Cytometry, Fluorescence Microscopy, Fluorescence Microscopy. |
Citations
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