FluoroFinder

	Supplier	US Biological
	Catalog #:	C2549-70-APC-100UL (View supplier product page)
	Size	100 μl
	Price	$789.00
	Antigen	Fbxw7
	Clone
	Host	Rabbit
	Isotype	IgG
	Conjugate	APC
	Target Species	Human
	Applications	IP, WB
	Description	Cdc4 (FBXW7, F-box and WD repeat domain containing 7, AGO, Archipelago homolog, DKFZp686F23254, F-box/WD repeat-containing protein 7, F-box and WD-40 domain-containing protein 7, F-box protein FBX30, FBW6, FBW7, FBX30, FBXO30, FBXW6, FLJ11071, FLJ16457, hAgo, hCdc4, SEL10, SEL-10) (APC) Pab

	Fbxw7	This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene was previously referred to as FBX30, and belongs to the Fbws class; in addition to an F-box, this protein contains 7 tandem WD40 repeats. This protein binds directly to cyclin E and probably targets cyclin E for ubiquitin-mediated degradation. Mutations in this gene are detected in ovarian and breast cancer cell lines, implicating the gene's potential role in the pathogenesis of human cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2012]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

	Additional Sources

Fbxw7 / APC /