FluoroFinder

	Supplier	US Biological
	Catalog #:	C2387-07B-APC-100UL (View supplier product page)
	Size	100 μl
	Price	$738.00
	Antigen	CD35
	Clone	3H1257, E11
	Host	Mouse
	Isotype	IgG1
	Conjugate	APC
	Target Species	Human
	Applications	IHC, WB
	Description	CD35 (CD35 Antigen, C3 Binding Protein, C3BR, Complement Component (3b/4b) Receptor 1 (Knops Blood Group), Complement Component Receptor 1, Complement Receptor 1, Complement Receptor Type 1, CR1, KN) (APC) Mab 3H1257, E11

	CD35	This gene is a member of the receptors of complement activation (RCA) family and is located in the 'cluster RCA' region of chromosome 1. The genome is polymorphic at this locus with allele-specific splice variants encoding different isoforms, based on the presence/absence of long homologous repeats (LHRs). The gene encodes a monomeric single-pass type I membrane glycoprotein found on erythrocytes, leukocytes, glomerular podocytes, and splenic follicular dendritic cells. The Knops blood group system is a system of antigens located on this protein. The protein mediates cellular binding to particles and immune complexes that have activated complement. Decreases in expression of this protein and/or mutations in this gene have been associated with gallbladder carcinomas, mesangiocapillary glomerulonephritis, systemic lupus erythematosus, sarcoidosis and Alzheimer's disease. Mutations in this gene have also been associated with a reduction in Plasmodium falciparum rosetting, conferring protection against severe malaria. [provided by RefSeq, May 2020]
	APC	Allophycocyanin (APC) is a fluorescent protein derived from cyanobacteria and red algae and a potent donor fluorophore to create tandem dyes that can be excited off the 633-640 nm laser. APC has an excitation peak at 650 nm and a emission peak at 660 nm.

	Additional Sources

CD35 / APC / 3H1257, E11