Caspase 10 / FITC / 1D8
Caspase 10 / FITC / 1D8
Product Details
| Supplier | US Biological | |
|---|---|---|
| Catalog #: | 244238-FITC-100UL (View supplier product page) | |
| Size | 100 μl | |
| Price | $681.00 | |
| Antigen | Caspase 10 | |
| Clone | 1D8 | |
| Host | Mouse | |
| Isotype | IgG1 κ | |
| Conjugate | FITC | |
| Target Species | Human | |
| Applications | ELISA | |
| Description | CASP10 (Caspase 10, Apoptosis-Related Cysteine Peptidase, ALPS2, FLICE2, MCH4) (FITC) Mab 1D8 |
About Caspase 10 and FITC
| Caspase 10 | This gene encodes a protein which is a member of the cysteine-aspartic acid protease (caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small, that dimerize to form the active enzyme. This protein cleaves and activates caspases 3 and 7, and the protein itself is processed by caspase 8. Mutations in this gene are associated with type IIA autoimmune lymphoproliferative syndrome, non-Hodgkin lymphoma and gastric cancer. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Apr 2011] | |
|---|---|---|
| FITC | Fluorescein isothiocyanate (FITC) has an excitation peak at 495 nm and an emission peak at 519 nm. The name FITC is a misnomer in that the isothiocyanate is a reactive form of this dye. Once FITC is conjugated to an antibody, it is simply Fluorescein conjugated. FITC is one of the most widely used dyes for fluorescent applications, therefore most instruments come standard with a 488 nm laser and FITC filter set up. FITC is commonly conjugated to secondary antibodies and used in applications such as flow cytometry, immunocytochemistry, and immunohistochemistry. FITC is relatively dim, sensitive to photobleaching and it is susceptible to changes is pH. There are better performing alternatives to FITC, like Vio®Bright 515, Alexa Fluor™ 488, iFluor® 488, CF®488A and DY-488. FITC is a long-time generic dye with no sole manufacturer or trademark. |
Citations
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