FluoroFinder

	Supplier	US Biological
	Catalog #:	123314-ML650-100UL (View supplier product page)
	Size	100 μl
	Price	$681.00
	Antigen	Androgen Receptor
	Clone	1G3
	Host	Mouse
	Isotype	IgG1 κ
	Conjugate	MaxLight 650
	Target Species	Human
	Applications	FC, IHC, WB
	Description	Androgen Receptor (Dihydrotestosterone Receptor, Nuclear Receptor Subfamily 3 Group C Member 4, AR, DHTR, NR3C4) (MaxLight 650) Mab 1G3

	Androgen Receptor	The androgen receptor gene is more than 90 kb long and codes for a protein that has 3 major functional domains: the N-terminal domain, DNA-binding domain, and androgen-binding domain. The protein functions as a steroid-hormone activated transcription factor. Upon binding the hormone ligand, the receptor dissociates from accessory proteins, translocates into the nucleus, dimerizes, and then stimulates transcription of androgen responsive genes. This gene contains 2 polymorphic trinucleotide repeat segments that encode polyglutamine and polyglycine tracts in the N-terminal transactivation domain of its protein. Expansion of the polyglutamine tract from the normal 9-34 repeats to the pathogenic 38-62 repeats causes spinal bulbar muscular atrophy (SBMA, also known as Kennedy's disease). Mutations in this gene are also associated with complete androgen insensitivity (CAIS). Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2017]
	MaxLight 650	MaxLight 650 is excited by the 640 laser and emission captured by the 670/30 filter. It can be used with the following analysis platforms: Labeling, Flow Cytometry, Fluorescence Microscopy, Fluorescence Microscopy.

	Additional Sources

Androgen Receptor / MaxLight 650 / 1G3