CD143 / MaxLight 650 / 2Q2317, 3G8
CD143 / MaxLight 650 / 2Q2317, 3G8
Product Details
| Supplier | US Biological | |
|---|---|---|
| Catalog #: | A2295-01E-ML650-100UL (View supplier product page) | |
| Size | 100 μl | |
| Price | $776.00 | |
| Antigen | CD143 | |
| Clone | 2Q2317, 3G8 | |
| Host | Mouse | |
| Isotype | IgG1 | |
| Conjugate | MaxLight 650 | |
| Target Species | Human | |
| Applications | FC, IHC, IP | |
| Description | Angiotensin Converting Enzyme (ACE, CD143) (MaxLight 650) Mab 2Q2317, 3G8 |
About CD143 and MaxLight 650
| CD143 | This gene encodes an enzyme involved in blood pressure regulation and electrolyte balance. It catalyzes the conversion of angiotensin I into a physiologically active peptide angiotensin II. Angiotensin II is a potent vasopressor and aldosterone-stimulating peptide that controls blood pressure and fluid-electrolyte balance. This angiotensin converting enzyme (ACE) also inactivates the vasodilator protein, bradykinin. Accordingly, the encoded enzyme increases blood pressure and is a drug target of ACE inhibitors, which are often prescribed to reduce blood pressure. This enzyme additionally plays a role in fertility through its ability to cleave and release GPI-anchored membrane proteins in spermatozoa. Many studies have associated the presence or absence of a 287 bp Alu repeat element in this gene with the levels of circulating enzyme. This polymorphism, as well as mutations in this gene, have been implicated in a wide variety of diseases including cardiovascular pathophysiologies, psoriasis, renal disease, stroke, and Alzheimer's disease. Regulation of the homologous ACE2 gene may be involved in progression of disease caused by several human coronaviruses, including SARS-CoV and SARS-CoV-2. Alternative splicing results in multiple transcript variants encoding both somatic (sACE) and male-specific testicular (tACE) isoforms. [provided by RefSeq, Sep 2020] | |
|---|---|---|
| MaxLight 650 | MaxLight 650 is excited by the 640 laser and emission captured by the 670/30 filter. It can be used with the following analysis platforms: Labeling, Flow Cytometry, Fluorescence Microscopy, Fluorescence Microscopy. |
Citations
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