53BP1 Monoclonal / Unconjugated / 6B3E10

Product Details
Supplier Thermo Fisher Scientific
Catalog #: MA5-38649 (View supplier product page)
Size 100 μg
Price $456.00
Antigen 53BP1
Clone 6B3E10
Host Mouse
Isotype IgG1
Conjugate Unconjugated
Target Species Human
Applications ELISA, FC, IHC-P, WB
Description 53BP1 Monoclonal Antibody (6B3E10)
About 53BP1 and Purified
53BP1 This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]
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Purified Excitation and Emission Spectra