Prohibitin / Unconjugated / PHB/3226

Product Details
Supplier NSJ Bioreagents
Catalog #: V7614-20UG (View supplier product page)
Size 20 μg
Price $252.00
Antigen Prohibitin
Clone PHB/3226
Host Mouse
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications WB, IHC-P
Description This antibody recognizes a protein of 30kDa which is identified as Prohibitin (PHB), an evolutionarily conserved protein with homologues found in yeast to man. It is located in the inner membrane of mitochondria. Although PHB mRNA and protein expression occurs throughout the cell cycle, maximum levels are detected during the G1/S phase transition and minimum levels are seen in S phase and the G2/mitosis boundary. Prohibitin is located exclusively in the mitochondria with the highest concentration on the inner membrane. It is an ideal mitochondrial marker. It shows anti-proliferative activity and has been proposed to play a role in normal cell cycle regulation, replicative senescence, cellular immortalization, and tumor suppression.
About Prohibitin and Purified
Prohibitin This gene is evolutionarily conserved, and its product is proposed to play a role in human cellular senescence and tumor suppression. Antiproliferative activity is reported to be localized to the 3' UTR, which is proposed to function as a trans-acting regulatory RNA. Several pseudogenes of this gene have been identified. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]
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Purified Excitation and Emission Spectra