IgG4 / Unconjugated / IGHG4/1345

Product Details
Supplier NSJ Bioreagents
Catalog #: V3454SAF-100UG (View supplier product page)
Size 100 μg
Price $554.00
Antigen IgG4
Clone IGHG4/1345
Host Mouse
Isotype IgG
Conjugate Unconjugated
Target Species Human
Applications IHC-P
Description The regions of relatively constant sequence beyond the variable regions of immunoglobulins are termed constant regions (C regions) and are present in both the heavy and light chains. With very few exceptions, the sites of attachment for carbohydrates on immunoglobulins are located in these C regions. These regions also function to hold the variable regions together by using the disulfide bond between them. The C regions facilitate interaction with the antigen by increasing the maximum rotation of the immunoglobulin arms. Reportedly, a large population of patients with recurrent respiratory tract infection has low IgG4 concentrations. IgG4-related sclerosing disease has been recognized as a systemic disease entity characterized by an elevated serum IgG4 level, sclerosing fibrosis, and diffuse lymphoplasmacytic infiltration with the presence of many IgG4-positive plasma cells. IgG4 is overexpressed in inflammatory pseudotumor (IPT) and under expressed in inflammatory myofibroblastic tumor (IMT). In pulmonary nodular lymphoid hyperplasia (PNLH), there are an increased number of IgG4+ plasma cells.
About IgG4 and Purified
IgG4 Predicted to enable antigen binding activity and immunoglobulin receptor binding activity. Predicted to be involved in several processes, including activation of immune response; defense response to other organism; and phagocytosis. Located in blood microparticle and extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
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Purified Excitation and Emission Spectra